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(Circulation. 1959;20:396.)
© 1959 American Heart Association, Inc.

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A Syndrome Featuring Defects of the Heart, Sternum, Diaphragm, and Anterior Abdominal Wall

I. HUNTER CRITTENDEN M.D.¹; FORREST H. ADAMS M.D.¹; DONALD G. MULDER M.D.¹

¹ From the Departments of Pediatrics and Surgery University of California, Los Angeles, Calif.

Three patients featuring a syndrome of defects of the heart, sternum, diaphragm, and anterior abdominal wall are presented. The striking similarity of the anomalies manifested by the 3 cases posed a question whether or not a recognized syndrome previously existed. In order to determine this, a search was made to find other such cases, and an attempt was made to establish a common embryologic pathogenesis. Review of the literature as well as extensive personal communication was carried out. Embryology of the involved organs was considered in order to determine a specific phase of defective development.

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