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(Circulation. 1959;20:864.)
© 1959 American Heart Association, Inc.

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Serum-Induced Thrombosis

Studies of its Induction and Evolution Under Controlled Conditions in Vivo

STANFORD WESSLER M.D.¹; LEOPOLD REINER M.D.¹; DAVID G. FREIMAN M.D.¹; STANLEY M. REIMER PH.D.¹; MORLEY LERTZMAN M.D.¹

¹ From the Medical Research Department of the Yamins Research Laboratory and the Department of Pathology, Beth Israel Hospital, and the Departments of Medicine and Pathology, Harvard Medical School, Boston, Mass.

A simple, reproducible, physiologic technic is delineated for the production and study of thromboembolism. The method is based on the observation that the infusion of serum, in striking contrast to plasma, induces massive thrombosis in vascular segments containing stagnant blood far removed from the site of infusion. Data are presented on the nature of the thrombosis-inducing activity of canine and human serum, on the effect of serum infusions on recipient animals, and on the morphology of the induced thrombus. The adaptability of this method to the study of a variety of thromboembolic phenomena in man is described.

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