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(Circulation. 1959;20:1011.)
© 1959 American Heart Association, Inc.

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Lipoproteins, Cholesterol and Serum Proteins as Predictors of Myocardial Infarction

IRVINE H. PAGE M.D.¹ LENA A. LEWIS PH.D.¹

¹ From the Research Division of the Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute, Cleveland, Ohio.

The normal variability of lipoprotein and cholesterol levels was established for 6 women over a period of 5 months for comparison with levels in people who develop myocardial infarction. We have studied 107 normal men for 7 years. Among these 11 developed infarction and 6 angina pectoris. Little change in lipid levels was associated with these events. Electrophoretic patterns early after infarction showed certain relatively characteristic changes, especially increase in -2 and globulins and fibrinogen. Low-density lipoprotein also increased. While -2 globulin was usually greatest in patients with the most extensive myocardial damage, there was little over-all correlation between lipoprotein pattern and severity of infarction. The "coronary profile" can be more sharply delineated by repeated lipid measurements because as a group those with atherosclerosis and infarction exhibit slightly elevated values.