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(Circulation. 1960;21:21.)
© 1960 American Heart Association, Inc.

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Hemodynamic and Hypotensive Effects of Long-term Therapy with Chlorothiazide

JAMES CONWAY M.D., PH.D.¹ PHILIP LAUWERS M.D.¹

¹ From the Hypertension Unit, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich.

Long-term treatment of hypertension with chlorothiazide alone produces mioderate reduction in blood pressure in 66 per cent of patients with hypertension. This fall in pressure is due to a reduction in total peripheral resistance rather than a fall in cardiac output.

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