This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by RUBIN, A. L. Articles by LUCKEY, E. H. Search for Related Content PubMed Articles by RUBIN, A. L. Articles by LUCKEY, E. H.

(Circulation. 1960;21:332.)
© 1960 American Heart Association, Inc.

---

The Use of L-Lysine Monohydrochloride in Combination with Mercurial Diuretics in the Treatment of Refractory Fluid Retention

ALBERT L. RUBIN M.D.¹; NORTON SPRITZ M.D.¹; ALLEN W. MEAD M.D.¹; RICHARD A. HERRMANN M.D.¹; WARREN S. BRAVEMAN M.D.¹; E. HUGH LUCKEY M.D.¹

¹ From the Cardiorenal Laboratory of the Second (Cornell) Medical Division, Bellevue Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y.

Administration of large doses of L-lysine monohydrochloride at meal times has proved to be an efficient method, free of significant side effects, for the production of a hyperchloremic acidosis to restore responsiveness to mercurial diuretics in cardiac and cirrhotic patients with refractory fluid retention. Results obtained in a group of 14 patients are presented and advantages of L-lysine monohydrochloride over previously available acidifying chloride salts are discussed.