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(Circulation. 1960;21:332.)
© 1960 American Heart Association, Inc.

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The Use of L-Lysine Monohydrochloride in Combination with Mercurial Diuretics in the Treatment of Refractory Fluid Retention

ALBERT L. RUBIN M.D.¹; NORTON SPRITZ M.D.¹; ALLEN W. MEAD M.D.¹; RICHARD A. HERRMANN M.D.¹; WARREN S. BRAVEMAN M.D.¹; E. HUGH LUCKEY M.D.¹

¹ From the Cardiorenal Laboratory of the Second (Cornell) Medical Division, Bellevue Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y.

Administration of large doses of L-lysine monohydrochloride at meal times has proved to be an efficient method, free of significant side effects, for the production of a hyperchloremic acidosis to restore responsiveness to mercurial diuretics in cardiac and cirrhotic patients with refractory fluid retention. Results obtained in a group of 14 patients are presented and advantages of L-lysine monohydrochloride over previously available acidifying chloride salts are discussed.

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