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(Circulation. 1961;23:370.)
© 1961 American Heart Association, Inc.

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The Synthesis of Phospholipids in Human Atheromatous Lesions

D. B. ZILVERSMIT PH.D.¹; ESTHER L. MCCANDLESS PH.D.¹; PAUL H. JORDAN JR. M.D.¹; WALTER S. HENLY M.D.¹; R. F. ACKERMAN M.D.¹; Anne Boals ¹

¹ From the Division of Physiology, University of Tennessee, Memphis, Tennessee.

Femoral arteries, abdominal aortas, one renal artery, and one coronary artery removed from patients injected with P³² phosphate showed in most instances an active incorporation of the label into the phospholipids of intima and adventitia. A comparison of the specific activities of arterial plaque and plasma phospholipids suggests that the excess arterial phospholipids are originally derived from synthesis by the arterial wall, or at least undergo continuous renewal in situ.

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