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(Circulation. 1962;26:1241.)
© 1962 American Heart Association, Inc.

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Mitral Regurgitant Flow and Left Ventricular Function in Patients with Mitral Valve Disease

ANTHONY D. JOSE M.A., M.R.C.P.¹ L. BERNSTEIN M.B., M.R.A.C.P.¹

¹ From the Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.

A direct indicator-dilution principle for measurement of regurgitant flow has been applied in the study of 39 patients with mitral valve disease.

Certain technical modifications in the procedure appear to have abolished the grossly anomalous results encountered previously, enabling a degree of reliance to be placed on the quantitative measurement.

With use of the measurement obtained, together with other hemodynamic data, the functional status of patients with mitral incompetence has been analyzed. The findings confirm that left ventricular failure, not mitral incompetence itself, underlies many of the criteria presently used to determine the severity of the disease, i.e., the presence of symptoms, the clinical and radiologic signs, and abnormalities in arterial dye dilution curves. These criteria are therefore probably not optimal ones on which to base selection of patients for surgical treatment, or to follow its results.