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(Circulation. 1963;27:36.)
© 1963 American Heart Association, Inc.

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Function of the Contralateral Kidney in Renal Hypertension Due to Renal Artery Stenosis

ALAN P. THAL M.D., PH.D.¹; THEODOR B. GRAGE M.D.¹; ROBERT L. VERNIER M.D.¹

¹ From the Departments of Surgery and Pediatrics, University of Minnesota Hospitals, Minneapolis 14, Minnesota.

Severe hypertension of at least 7 years' duration, due to coarctation of the right renal artery, was treated by reconstruction of the abnormal artery and restoration of blood flow to the coarcted kidney. Renal biopsies revealed normal microscopic architecture in the right kidney and advanced hypertensive pathology in the opposite kidney. After 8 months' observation of persistent, moderate hypertension, the left kidney was removed with prompt return of blood pressure to normal levels during the subsequent 2 years.

These observations demonstrate the precise correlation of hypertension due to renal artery stenosis in the human with the experimental model in rats.