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(Circulation. 1963;27:5.)
© 1963 American Heart Association, Inc.

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Prevention of Ventricular Tachycardia and Fibrillation by Intravenous Isoproterenol and Epinephrine

ARTHUR J. LINENTHAL M.D.¹ PAUL M. ZOLL M.D.¹

¹ From the Medical Research Department, Beth Israel Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.

Isoproterenol and epinephrine were given intravenously in dilute solutions to nine patients with Stokes-Adams attacks due to ventricular tachycardia and fibrillation. The drugs produced ventricular acceleration and thereby controlled the attacks. This technic proved useful for prompt, short-term prevention of seizures; for the long term, direct electric stimulation with internal pacemakers was required.