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(Circulation. 1963;27:512.)
© 1963 American Heart Association, Inc.

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Hemodynamic Effects of Isoproterenol Infusion in Patients with Normal and Diseased Mitral Valves

ROBERT E. WHALEN M.D.¹; ALLAN I. COHEN M.D.¹; ROBERT G. SUMNER M.D.¹; HENRY D. McINTOSH M.D.¹

¹ From the Cardiovascular Laboratory, Department of Medicine, Duke Medical Center, Durham, North Carolina.

Hemodynamic effects of isoproterenol infusion were studied in 26 patients with and without mitral valve disease undergoing combined right and left heart catheterization. The heart rate and cardiac output rose while the left ventricular end-diastolic pressure, pulmonary vascular resistance, and total peripheral resistance fell, regardless of the status of the mitral valve. Infusion produced little change in the mean arterial blood pressure and the diastolic filling period per minute.

While the mean left atrial and pulmonary artery pressures fell in patients with normal or insufficient valves, these pressures rose in patients with mitral stenosis. Stroke volume tended to rise in all patients but those with mitral stenosis. In patients with combined mitral stenosis and insufficiency the insufficiency appeared to modify the hemodynamic response associated with mitral stenosis.

The presence of a lowered end-diastolic pressure in the left ventricle and an increased pressure in the left atrium in patients with stenosis suggests that isoproterenol has a direct or reflex effect on the left ventricle during diastole.

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