This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by COWLEY, R. A. Articles by HAWTHORNE, I. Search for Related Content PubMed Articles by COWLEY, R. A. Articles by HAWTHORNE, I.

(Circulation. 1963;27:670.)
© 1963 American Heart Association, Inc.

---

Electrocardiographic and Biochemical Study in Hemorrhagic Shock in Dogs Treated with Hyperbaric Oxygenation

R. ADAMS COWLEY M.D.¹; SAFUH ATTAR M.D.¹; WILLIAM G. ESMOND M.D.¹; EMIL BLAIR M.D.¹; ILSE HAWTHORNE B.S.¹

¹ From the Division of Thoracic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

A modification of the standard Fine preparation for hemorrhagic shock yielding an 83 per cent mortality rate was developed. Hyperbaric oxygenation (OHP) at 3 atmospheres absolute was found to decrease the mortality rate significantly, to 26 per cent. Electrocardiographic changes induced by OHP were bradycardia and sinus arrhythmia, which were abolished by vagotomy. Tachycardia, depression of the S-T segment, with changes in the configuration of the T wave that indicated myocardial damage, was observed in shock dogs treated with OHP. All changes improved after decompression and reinfusion of shed blood. The improved survival rate is attributed to better oxygenation of the hypoxic tissues [see figure in the PDF file] by the increased physically dissolved oxygen.

This article has been cited by other articles:

				R. Ollodart and E. Blair High-Pressure Oxygen as an Adjunct in Experimental Bacteremic Shock JAMA, March 1, 1965; 191(9): 736 - 739. [Abstract] [PDF]