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(Circulation. 1963;27:713.)
© 1963 American Heart Association, Inc.

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Neural Responses Following Autotransplantation of the Canine Heart

VALLEE L. WILLMAN M.D., F.A.C.S.¹; THEODORE COOPER M.D., PH.D.¹; LOUIS G. CIAN M.D.¹; C. ROLLINS HANLON M.D., F.A.C.S.¹

¹ From the Department of Surgery and Center for Cardiovascular Research, St. Louis University, St. Louis, Missouri.

Orthotopic autotransplantation of the canine heart is followed by loss of direct sympathetic and parasympathetic neural regulation. Stimulation of the vagus nerve or stellate ganglion fails to alter cardiac rate.

Myocardial catecholamines are depleted and [see figure in the PDF file] hypersensitivity to exogenous l-norepinephrine is present for months.

One year after the operation, there is evidence of cardiac reinnervation and return of normal responses to catecholamines.

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