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(Circulation. 1963;27:1050.)
© 1963 American Heart Association, Inc.

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The Quantitative Determination of Renin in the Plasma of Patients with Arterial Hypertension

OSCAR M. HELMER PH.D.¹; WALTER E. JUDSON M.D.¹; R. M. Sanders ¹

¹ From the Lilly Laboratory for Clinical Research, Marion County General Hospital, and the Indiana University School of Medicine, Indianapolis, Indiana.

A method was described for the quantitative determination of renin in small amounts of dialyzed human plasma, utilizing the first order reaction constant.

A wide variation was found in the renin-substrate (angiotensinogen) content of plasma of patients with arterial hypertension. Many of these patients had high concentrations of this factor.

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