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(Circulation. 1963;28:404.)
© 1963 American Heart Association, Inc.

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Effect of Exercise on Cardiac Performance in Human Subjects with Coronary Artery Disease

JOSEPH V. MESSER M.D.¹; HERBERT J. LEVINE M.D.¹; RICHARD J. WAGMAN M.D.¹; RICHARD GORLIN M.D.¹

¹ From the Medical Clinics, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts.

Cardiac performance and oxygenation have been studied in resting and exercising subjects with coronary artery disease. Disturbances exist in myocardial function and energetics, characterized by preservation of pressure development, but with impaired systolic ejection and failure to increase mechanical efficiency during exercise. Resultant elevation of myocardial oxygen need by impaired performance undoubtedly aggravates coronary reserve inadequacy during exercise.