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(Circulation. 1951;3:171.)
© 1951 American Heart Association, Inc.

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Clinical Evaluation of Dicumarinyl Derivatives with a Metabolic Study of the Radioactively Labeled Anticoagulants in Animals

ERIC P. HAUSNER M.D.; CHARLES L. SHAFER M.D.; MARION CORSON ; OGDEN JOHNSON ; THEODORE TRUJILLO ; WRIGHT LANGHAM

The common use of dicumarinyl derivatives for the treatment of thromboembolic diseases justifies further clinical evaluation of dicumarol and 4,4'-dihydroxydicumarinyl ethyl acetate [Pelentan, Tromexan, 3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester.]

The need for a more thorough understanding of the pharmacodynamic action of dicumarinyl anticoagulants has prompted a study of their gross metabolism in animals, using C¹⁴-labeled materials.

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