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(Circulation. 1951;3:254.)
© 1951 American Heart Association, Inc.

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The Effect of "Sympatholytic Drugs on the Cardiovascular Responses to Epinephrine and Norepinephrine in Man

EDWARD D. FREIS M.D.¹; J. CALVIN MACKAY M.D.¹; WILLIAM F. OLIVER M.D.¹

¹ From the Medical Service, Veterans Administration Hospital, Washington, D. C.

Under controlled conditions the effects of various "sympatholytic" agents on the cardiovascular responses to epinephrine and norepinephrine were compared in man. The dosages of the sympatholytic drugs administered approximated those usually employed clinically. Such basic data are given for the following agents: Dibenamine, the imidazoline derivatives [Priscoline and Regitine (C-7337)], the dihydrogenated alkaloids of ergot (D.H.K. and C.C.K.), L-hydrazinophthalazine (C-5968), tetraethylammonium, and hexamethonium (C6).

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