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(Circulation. 1951;3:260.)
© 1951 American Heart Association, Inc.

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Effects of Bleeding on Electrolyte Excretion and on Glomerular Filtration

T. A. LOMBARDO M.D.¹; SEYMOUR EISENBERG M.D.¹; B. B. OLIVER M.D.¹; W. N. VIAR M.D.¹; E. E. EDDLEMAN JR. M.D.¹; T. R. HARRISON M.D.¹

¹ From the Department of Internal Medicine, Southwestern Medical School of the University of Texas, Dallas, Texas.

Removal of small amounts of blood from sitting subjects caused reduction of sodium excretion without alterations in creatinine clearance, or in apparent cardiac output (electrokymographic method). This reduction could be prevented by compression of the neck. The experiments support the concept of an homeostatic central mechanism which regulates the volume of extracellular fluid by altering sodium excretion. If such a mechanism exists it is apparently activated by changes in the volume of body fluids rather than by changes in cardiac output.

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