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(Circulation. 1951;3:722.)
© 1951 American Heart Association, Inc.

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Blood Pressure in the Unanesthetized Rat. I

FREDERICK OLMSTED ¹; A. C. CORCORAN M.D.¹; IRVINE H. PAGE M.D.¹

¹ From the Research Division and Frank E. Bunts Educational Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Methods of indirectly determining blood pressure in the rat are reviewed and their drawbacks noted. A new method is described which has the advantage of objectivity and provides permanent graphic record of each determination. The end point used is the reappearance of pulsation in the foot distal to a slowly deflating leg cuff. Application of the method is described and its use compared with tail plethysmography.