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Circulation. 1965;31:661-664

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(Circulation. 1965;31:661.)
© 1965 American Heart Association, Inc.

Hypotensive Effect of Ethacrynic Acid

JAMES CONWAY M.D., PH.D.1 GASTONE LEONETTI M.D.1

1 From the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.

Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood pressure averaging 48/18 mm. Hg was obtained.






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