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(Circulation. 1965;32:394.)
© 1965 American Heart Association, Inc.

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Renal Performance in Patients Undergoing Replacement of the Aortic Valve

JOHN E. MIELKE M.D.¹; FRANK T. MAHER M.D., PH.D.¹; JAMES C. HUNT M.D., M.S.¹; JOHN W. KIRKLIN M.D., M.S.¹

¹ From the Mayo Clinic and the Mayo Graduate School of Medicine, University of Minnesota, Rochester, Minnesota.

Renal performance of seven patients undergoing replacement of the aortic valve was investigated. The initial portion of cardiopulmonary bypass was characterized by low arterial blood pressure and anuria. With a subsequent rise in arterial pressure during bypass, urine flow suddenly increased in five patients. In two patients urine flow did not resume until immediately after cardiopulmonary bypass. The high rate of urine flow at these times is thought to be partially due to a glucose-induced osmotic diuresis. The glomerular filtration rate (inulin clearance) and the effective renal plasma flow (PAH clearance) fell with induction of anesthesia and opening of the chest, but there was no further drop in these functions as a result of total body perfusion. Urine osmolality fell significantly during and immediately after cardiopulmonary bypass. The changes in urine osmolality are thought to be due in part to the osmotic diuresis and in part to a temporary reduction in the renal medullary hyperosmolality secondary to hemodynamic changes. All of the alterations in renal function were reversible in the patients studied.

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