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(Circulation. 1966;33:I-65.)
© 1966 American Heart Association, Inc.

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Role of Atelectasis in Surfactant Abnormalities Following Extracorporeal Circulation

A Clinical and Experimental Study

JAMES L. GUEST JR. M.D.¹; SRBOLJUB M. SEKULIC M.D.¹; THOMAS J. YEH M.D.¹; LOIS T. ELLISON M.D.¹; ROBERT G. ELLISON M.D.¹

¹ From the Departments of Surgery (Thoracic) and Physiology, Medical College of Georgia, Augusta, Georgia.

Surface activity of lung extracts was determined in 36 patients and 28 dogs following extracorporeal circulation. Normal results were usually found. Abnormal surface tension was demonstrated only in a few samples obtained from grossly atelectatic or congested portions of lung, normal surface tension being present in adjoining areas of the same lung. Sources of error in surface-tension measurements and factors to be considered in the interpretation of results are discussed. A possible explanation for the discrepancies in results obtained by various investigators is presented.