This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MCPHAUL, J. J. Articles by GROLLMAN, A. Search for Related Content PubMed PubMed Citation Articles by MCPHAUL, J. J., JR. Articles by GROLLMAN, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Kidney Diseases Hazardous Substances DB VASOPRESSIN

(Circulation. 1966;33:781.)
© 1966 American Heart Association, Inc.

---

Correlation of the Pressor Activity of the Renal Venous Effluent with Excretory Function and Other Tests in Focal, Parenchymal, and Vascular Renal Disease

JOHN J. MCPHAUL JR. USAF MC¹; DUNCAN A. MCINTOSH USAF MC¹; LESTER F. WILLIAMS USAF MC¹; EMIL J. GRITTI USAF MC¹; ARTHUR GROLLMAN M.D., PH.D.¹

¹ From the Departments of Medicine and Surgery, Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, San Antonio, Texas, and the Department of Experimental Medicine, University of Texas Southwestern Medical School, Dallas, Texas.

A series of 170 hypertensive patients suspected of suffering from renovascular disease have been subjected to various tests designed to identify the presence of a surgically remediable lesion.

The presence of a pressor agent in the renal venous effluent, as determined by bioassay on the rat, has proven to be an accurate method for detecting the presence of renovascular hypertension responsive to surgical treatment. Split-function excretory tests, aortography, and other tests used for this purpose could not be relied on as the sole criterion as to whether surgical intervention is indicated in a given patient.