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(Circulation. 1967;35:I-206.)
© 1967 American Heart Association, Inc.

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Effect of Total Cardiopulmonary Bypass on Human Lung Elastic Properties

EMIL BLAIR M.D.¹; ULF HEDSTRAND M.D.¹; CARL-JOHANN WESTERHOLME M.D.¹; VIKING O. BJÖRK M.D.¹

¹ From the Department of Surgery (Thoracic), the University of Vermont College of Medicine, Burlington, Vermont, and the Departments of Thoracic Surgery and Anesthesiology, University Hospital, Uppsala, Sweden. A portion of this work was completed at the University of Maryland School of Medicine, Baltimore, Maryland.

Quasi-static elastic properties and dynamic compliances were measured in a series of patients undergoing open-heart surgery with total cardiopulmonary bypass for periods up to 2 hours. The data revealed that in half of the patients no alterations occurred, and in the other half there appeared a distinct improvement in lung mechanics, as indicated by the elastic properties. The reasons for this improvement are not known but may be related in part to changes in pulmonary blood volume. Artificial perfusion per se for around 2 hours causes no significant impairment in the elastic component of lung mechanics.