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(Circulation. 1967;35:I-92.)
© 1967 American Heart Association, Inc.

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Resuscitation and Function of the Cadaver Heart

ROBERT D. WUERFLEIN M.D.¹ NORMAN E. SHUMWAY M.D.¹

¹ From the Department of Surgery, Division of Cardiovascular Surgery, Stanford University School of Medicine, Palo Alto, California.

Cadaver dog hearts with anoxia for one and one-half hours and no cooling were revived with 70% (18 of 26) success. There was occasional success after one and one-half to two hours of anoxia. At two hours no heart could be revived. After resuscitation cadaver hearts were maintained in a functional heart-lung preparation for periods up to 30 hours. Attempts were made to transplant ten of these hearts into the orthotopic position. There were no long-term survivors; all ten, however, were able to take over the circulatory load after bypass. Four dogs maintained an adequate circulation without supportive drugs for from eight to 38 hours.