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(Circulation. 1967;35:1141.)
© 1967 American Heart Association, Inc.

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Takayasu's Arteritis

Clinical Report of Eighty-four Cases and Immunological Studies of Seven Cases

KIKU NAKAO M.D.¹; MASAO IKEDA M.D.¹; SHIN-ICHI KIMATA M.D.¹; HIROKAZU NIITANI M.D.¹; MITSUO MIYAHARA M.D.¹; ZEN-ICHI ISHIMI M.D.¹; KUNITAKE HASHIBA M.D.¹; YOSHIYUKI TAKEDA M.D.¹; TOSHIO OZAWA M.D.¹; SATORU MATSUSHITA M.D.¹; MORIO KURAMOCHI M.D.¹

¹ From the Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo, Tokyo; the First Department of Internal Medicine, Faculty of Medicine, Showa University, Hiratsuka, Shinagawa-ku, Tokyo; the Second Department of Internal Medicine, Sapporo Medical College, Sapporo, Hokkaido; Cardiovascular Unit, Tora-no-mon Hospital, Minato-ku, Tokyo; the First Department of Internal Medicine, Nagasaki University, Nagasakishi; and the First Department of Internal Medicine, Faculty of Medicine, Toho University, Ohta-ku, Tokyo, Japan.

The manifestations of Takayasu's arteritis of the aorta were studied in 84 patients. The extent of the involvement of the aorta was classified on aortographic examination in 54 patients and from the clinical manifestations in 30. Involvement of the aorta was classified as: (1) arch type in 47 cases; (2) extensive type (whole aorta and its branches involved) in 27 cases; and (3) descending thoracic and abdominal type (only descending thoracic and abdominal aortas involved) in 10 cases. The three types resembled one another in clinical manifestations and laboratory findings except for ischemic signs which varied with the type of lesion and a slight difference in the ratio of male to female patients. Generalized, cardiac and pulmonary symptoms were noted by about two thirds of the patients in the early stage. About one third complained of local pain. The erythrocyte sedimentation rate and C-reactive protein were high values during the active stage of this disease. The hemagglutination test using tannic acid-treated erythrocytes was positive in five of seven cases. It is not clear yet that circulating anti-arterial antibodies are the direct cause of Takayasu's arteritis.

Key Words: Arterial occlusion • Rheumatoid disorders • Coarctation of aorta • Anti-arterial antibodies • Aortography

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