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(Circulation. 1967;36:175.)
© 1967 American Heart Association, Inc.

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A Comparative Study of Nitroglycerin and Propranolol

ERWIN ROBIN M.D.¹; CHARLES COWAN M.D.¹; PRITPAL PURI M.D.¹; SUNILENDU GANGULY M.D.¹; EMILE DEBOYRIE M.D.¹; MILA MARTINEZ M.D.¹; THOMAS STOCK M.D.¹; RICHARD J. BING M.D.¹

¹ From the Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan.

The action of sublingual nitroglycerin (0.6 mg) and intravenous propranolol (0.1 mg/kg) on shortening of right ventricular fibers was investigated in patients with and without coronary artery disease. This was accomplished with a newly devised strain gauge catheter. Hemodynamic parameters and changes in the oxidation-reduction potential of heart muscle were determined. Nitroglycerin results in decrease in shortening and velocity of shortening of ventricular fibers, heart rate, left ventricular end-diastolic and systemic pressure, dp/dt, tension-time index, stroke index, peripheral resistance, and left ventricular minute work in normal and arteriosclerotic subjects. Intravenous propranolol leads to a fall in velocity of shortening of myocardial fibers, heart rate, dp/dt, stroke index, and left ventricular minute work. However, there is an increase in tension-time index and peripheral resistance with no change in systemic pressure. Left ventricular end-diastolic pressure rises significantly in arteriosclerotic patients. The myocardial oxidation-reduction potential increases after nitroglycerin whereas it falls after propranolol in normal and arteriosclerotic patients.

Key Words: Hemodynamics • Lactic-pyruvic acid ratio • Velocity of fiber shortening • Oxidation-reduction potential

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