This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by AMERY, A. Articles by CONWAY, J. Search for Related Content PubMed PubMed Citation Articles by AMERY, A. Articles by CONWAY, J.

(Circulation. 1967;36:231.)
© 1967 American Heart Association, Inc.

---

Influence of Hypertension on the Hemodynamic Response to Exercise

ANTOON AMERY M.D.¹; STEVO JULIUS M.D., SC.D.¹; LEIGH S. WHITLOCK PH.D.¹; JAMES CONWAY M.D., PH.D.¹

¹ From Clinical Physiology Laboratory, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Sixty-one asymptomatic hypertensive patients from 19 to 68 years of age were subjected to a progressive exercise test on a cycle ergometer. A decline in maximal oxygen consumption and cardiac output and an increase in systolic blood pressure were observed with age. These findings were similar to those observed in normal subjects. In the middle-aged (35 to 49 years) and older subjects (50 to 60 years), the systolic pressure showed a greater increase with exercise than in normals of their age, but this did not apply to subjects aged 19 to 34 years. The cardiac response to exercise was normal at rest and at all levels of exercise in the middle-aged group, but the oldest group showed a reduced maximum cardiac output. In the youngest age group, cardiac output was normal at rest but fell below normal at all levels of exercise.

Maximal voluntary oxygen consumption and cardiac output were significantly reduced with increasing severity of hypertension.

Key Words: Aging • Arterial blood pressure • Cardiac output • Peripheral resistance • Oxygen consumption

This article has been cited by other articles:

				R. H. Fagard, K. Pardaens, J. A. Staessen, and L. Thijs Prognostic Value of Invasive Hemodynamic Measurements at Rest and During Exercise in Hypertensive Men Hypertension, July 1, 1996; 28(1): 31 - 36. [Abstract] [Full Text]

				K. A. Jamerson, S. D. Nesbitt, J. V. Amerena, E. Grant, and S. Julius Angiotensin Mediates Forearm Glucose Uptake by Hemodynamic Rather Than Direct Effects Hypertension, April 1, 1996; 27(4): 854 - 858. [Abstract] [Full Text]