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(Circulation. 1967;36:441.)
© 1967 American Heart Association, Inc.

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The Measurement of Glomerular Filtration Rate and Effective Renal Plasma Flow in Man by Iothalamate ¹²⁵I and Iodopyracet ¹³¹I

CHARLES M. ELWOOD M.D.¹ EUGENE M. SIGMAN M.D.¹

¹ From the State University of New York at Buffalo, School of Medicine, and the Buffalo General Hospital, Departments of Internal Medicine and Urology, Buffalo, New York.

In 21 patients, 90 simultaneous renal clearances of inulin and sodium iothalamate ¹²⁵I, and para-amino-hippuric acid (PAH) and iodopyracet ¹³¹I were determined by a constant infusion technique. The activities of iothalamate ¹²⁵I and iodopyracet ¹³¹I were determined simultaneously in a dual-channel scintillation counter. The concentrations of inulin and PAH were determined by standard chemical techniques. The ratio of iothalamate ¹²⁵I to inulin clearance ranged from 0.93 to 1.09 with a mean of 1.00. The ratio of iodopyracet ¹³¹I to PAH clearance varied from 0.86 to 1.04 with a mean of 0.96. The chemical determination of PAH and inulin required approximately 8 hours of technician time as compared with 30 minutes by the radioactive technique. The determination of the renal clearances of iothalamate ¹²⁵I and iodopyracet ¹³¹I is an accurate and time-saving technique for the measurement of glomerular filtration rate and effective renal plasma flow.

Key Words: Inulin • PAH