This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by BRISTOW, J. D. Articles by GRISWOLD, H. E. Search for Related Content PubMed PubMed Citation Articles by BRISTOW, J. D. Articles by GRISWOLD, H. E.

(Circulation. 1968;37:393.)
© 1968 American Heart Association, Inc.

---

Late, Heparin-Induced Bleeding after Retrograde Arterial Catheterization

J. DAVID BRISTOW M.D.¹; ARTHUR J. SEAMAN M.D.¹; FRANK E. KLOSTER M.D.¹; RODNEY H. HERR M.D.¹; HERBERT E. GRISWOLD M.D.¹

¹ From the Divisions of Cardiology and Hematology, Department of Medicine, University of Oregon Medical School, Portland, Oregon.

Three patients with ball-valve prostheses were given heparin after percutaneous retrograde aortic catheterization from the femoral artery. The drug was given prophylactically in one case and because of the development of signs of systemic embolism soon after catheterization in the other two. After 3 or more days of heparin therapy, serious bleeding developed at the site of percutaneous catheter entry. The timing and incidence of this complication are in marked contrast to experience with this procedure in individuals who did not receive heparin.

Preliminary experience is presented from right and left heart catheterizations in patients whose prothrombin-proconvertin times were allowed to remain in or near the therapeutic range. No hemorrhagic complications were observed.

Key Words: Hemorrhage • Anticoagulation • Phenindione • Warfarin