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(Circulation. 1968;37:II-168.)
© 1968 American Heart Association, Inc.

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Use of a Polyol in the Prevention of Hemolysis due to an Antifoam Agent in Pump Oxygenators

ROE WELLS M.D.¹; M. STELLAN BYGDEMAN M.D.¹; ALI A. SHAHRIARI M.D.¹; JACK M. MATLOFF M.D.¹; DWIGHT E. HARKEN M.D.¹

¹ From the Departments of Medicine and Surgery, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts.

Studies of the hematological effects of a polymethylsiloxane defoaming agent used in pump oxygenators have shown it to have significant hemolytic properties. This action is principally a direct one upon the red cell and requires some degree of associated mechanical stress. Pluronic, a nonionic emulsion stabilizer prevents the hemolytic process without interfering with the defoaming process.