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(Circulation. 1968;37:1000.)
© 1968 American Heart Association, Inc.

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Left Atrial Rhythm

Experimental Production in Man

BARRY C. HARRIS M.D.¹; JAMES A. SHAVER M.D.¹; SAMUEL GRAY III M.D.¹; FRANK W. KROETZ M.D.¹; JAMES J. LEONARD M.D.¹

¹ From the Department of Medicine, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Various criteria have been proposed for the diagnosis of left atrial rhythm (LAR) in previous experimental and electrocardiographic studies. Differentiation from A-V junctional rhythms remains ill-defined. In order to assess the left atrial (LA) P wave and to define LAR, the P wave and loop were studied by direct LA pacing in 11 patients undergoing diagnostic transseptal left heart catheterization. Experimental LAR produced changes in P-wave configuration and polarity. These changes were most obvious in lead V₁ and indicated reversal of the sequence and direction of activation with left atrial preceding right atrial depolarization. A typical "dome and dart" P wave occurred in two studies. P-wave configuration in leads I and V₆ was highly variable; frequent orientation of the LA P vector within the transitional zone of the horizontal electrical axis was thought to be responsible. The LA P loop showed reversal of the direction of inscription of the initial forces, indicating a change in the pattern of atrial depolarization. Stimulation of the appendage produced left-to-right spread of atrial depolarization, whereas activation of the main body was directed primarily anteriorly. Impulse formation in the right side of the posterior wall was usually directed from right to left. When the postero-inferior area was activated, the anterior P vector became directed superiorly, and resembled that of coronary sinus rhythm (CSR) in the frontal plane.

This study indicates that the P wave in lead V₁ is most important in the diagnosis of LAR; inversion of the P wave in lead V₆ is not essential. LAR can usually be differentiated from CSR, since in the horizontal plane, activation of the LA main body is more anteriorly directed than the spatial P vector of CSR.

Key Words: Arrhythmia • Ectopic atrial pacemaker • Left atrial pacing • Atrial activation • Left atrial P wave • Atrial vectorcardiogram • Left atrial P loop

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