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(Circulation. 1969;39:287.)
© 1969 American Heart Association, Inc.

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Study of Atrioventricular Conduction in Man Using Electrode Catheter Recordings of His Bundle Activity

ANTHONY N. DAMATO M.D.¹; SUN H. LAU M.D.¹; RICHARD H. HELFANT M.D.¹; EMANUEL STEIN M.D.¹; WALTER D. BERKOWITZ M.D.¹; STAFFORD I. COHEN M.D.¹

¹ From the Cardiopulmonary Laboratory, U. S. Public Health Service Hospital, Staten Island, New York.

The technique of recording electrograms of the His bundle, using a tripolar electrode catheter positioned across the tricuspid valve, was applied in a physiological study of atrioventricular conduction in man. Increasing the heart rate to 160 beats/min by right atrial pacing produced progressive prolongation of the P-H interval while the H-Q interval remained constant. At any given paced heart rate, digitalis caused a prolongation of the P-H interval. Isoproterenol and atropine markedly shortened the P-H interval at any given heart rate. Neither drug had any significant effect on the H-Q interval. Coupled premature atrial stimulation produced prolongation of the P-H interval alone when the resultant ventricular depolarization was normal, and prolongation of both the P-H and H-Q intervals when the resultant ventricular depolarization was aberrant.

Key Words: Digitalis • Isoproterenol • Atropine • Right atrial pacing

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