1 From the Department of Medicine (Division of Clinical Pharmacology) and the Medical Services of Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia.
The hemodynamic responses to isoproterenol and dopamine were investigated in 22 patients with the shock syndrome from various etiologies. Dopamine was superior to isoproterenol in seven patients with normal or low peripheral resistance. In this group of patients administration of isoproterenol was associated with unacceptably low blood pressure. Isoproterenol was superior in three patients in whom dopamine did not increase cardiac output. Both amines produced adequate clinical response in four patients, and a combination of isoproterenol and dopamine was necessary for adequate therapy in two patients. Six patients did not respond hemodynamically or clinically to either dopamine or isoproterenol. This investigation has demonstrated that optimal sympathomimetic amine therapy of shock is facilitated by an analysis of hemodynamic status and responses to drug administration.
© 1969 American Heart Association, Inc.
A Hemodynamic Comparison of Dopamine and Isoproterenol in Patients in Shock
Key Words: Hemodynamics of shock • Cardiac output • Peripheral resistance
This article has been cited by other articles:
 |
|
 |
|
  G. S. Francis and S. L. Archer Diagnosis and Management of Acute Congestive Heart Failure in the Intensive Care Unit J Intensive Care Med, March 1, 1989; 4(2): 84 - 92. [Abstract] [PDF]
|
|
|
|
 |
|
 M. D. Guazzi, P. G. Agostoni, E. Doria, A. Loaldi, M. Pepi, and A. Polese Hemodynamic Response to Oral Prenalterol in Dilated Decompensated Cardiomyopathy as a Result of Cardiac and Vascular Effects Angiology, December 1, 1985; 36(12): 857 - 866. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Shahar, D. Lotan, and Z. Barzilay Dopamine-induced Paroxysmal Supraventricular Tachycardia in an Infant Clinical Pediatrics, August 1, 1981; 20(8): 541 - 543. [Abstract] [PDF]
|
|