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(Circulation. 1969;39:611.)
© 1969 American Heart Association, Inc.

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Possible X-Linked Congenital Heart Disease

PATRICIA L. MONTELEONE M.D.¹ LEONARD F. FAGAN M.D.¹

¹ From the Department of Pediatrics, St. Louis University School of Medicine, and the Genetic and Cardiology Units, Cardinal Glennon Memorial Hospital for Children, St. Louis, Missouri.

Four male members of a family are known to have congenital mitral and aortic insufficiency, a fifth male has congenital mitral insufficiency only, and a sixth male had congenital heart disease by history. The involved males comprised all males in three generations of this family. Chromosomal and dermatoglyphic studies of the two living affected males are normal.

The involvement of males in this family is best explained on the basis of X-linked recessive inheritance. To our knowledge, this is the first report of possible X-linked inheritance of isolated congenital heart disease.

Key Words: Mitral insufficiency • Dermatoglyphic studies • Aortic insufficiency • Chromosomal studies • Tricuspid insufficiency

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