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(Circulation. 1969;39:I-253.)
© 1969 American Heart Association, Inc.

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Bacteremia and Thrombus on Prosthetic Heart Valves in Dogs

RICHARD D. JONES PH.D.¹; MOTOICHI AKAO M.D.¹; FREDERICK S. CROSS M.D., PH.D.¹

¹ From the Department of Surgical Research, Division of Surgery, Saint Luke's Hospital, Cleveland, Ohio.

Gram-negative bacteria are a frequent contaminant during cardiopulmonary bypass in dogs. The source of bacteria may be the donor blood or the experimental animal, presumably as a consequence of release from the gastrointestinal tract. The bacteremia is easily controlled with prophylactic cephaloridine therapy. Over 90% of dogs living more than one day after prosthetic valve replacement have survived for longer than one month. Control of this bacteremia allows meaningful evaluation of heart valve prostheses in the dog.