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(Circulation. 1951;4:229.)
© 1951 American Heart Association, Inc.

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The Effect of Amytal on the Cardiac Output and Peripheral Resistance of Man

PAUL WINCHELL M.D.¹; HENRY LONGSTREET TAYLOR PH.D.¹; CARLETON B. CHAPMAN M.D.¹

¹ From The Laboratory of Physiological Hygiene and the Department of Medicine, University of Minnesota, Minneapolis, Minn.

Measurements of cardiac output and intra-arterial pressure on 5 normal young men and 5 hypertensive patients before and during sedation with Amytal demonstrated a decreased cardiac output and an increased peripheral resistance during the period of sedation. It is concluded that the theoretic basis for the use of Amytal sedation as a device for selection of hypertensive patients for sympathectomy is not valid.

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