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(Circulation. 1951;4:262.)
© 1951 American Heart Association, Inc.

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Effects of Desoxycorticosterone Acetate on Cholesterolemia, Blood Pressure and Atherogenesis in Chicks

J. STAMLER M.D.¹; R. PICK M.D.¹; L. N. KATZ M.D.¹; E. Levinson ¹; P. Johnson ¹; M. Dudley ¹; C. Bolene ¹

¹ From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago, Illinois.

Chronic exhibition of chicks to desoxycorticosterone acetate produces a slight but definite rise in blood pressure. This effect is increased by addition of salt to the diet. This regimen does not affect cholesterol levels and atherogenesis in the chick on ordinary mash. However, in the presence of a mildly atherogenic diet (0.25 per cent cholesterol) concomitant DCA exhibition increases the incidence and severity of atherosclerosis.

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