This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HARVEY, R. M. Articles by ALEXANDER, J. K. Search for Related Content PubMed PubMed Citation Articles by HARVEY, R. M. Articles by ALEXANDER, J. K.

(Circulation. 1951;4:366.)
© 1951 American Heart Association, Inc.

---

Some Effects of Digoxin on the Heart and Circulation in Man

Digoxin in Enlarged Hearts Not in Clinical Congestive Failure

RÉJANE M. HARVEY M.D.¹; M. IRENÉ FERRER M.D.¹; RICHARD T. CATHCART M.D.¹; JAMES K. ALEXANDER M.D.¹

¹ From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Cardiopulmonary Laboratory of the First Medical and Chest Services (Columbia University Division), Bellevue Hospital, New York, N. Y.

The early effect of intravenous Digoxin was observed in 12 patients with cardiac enlargement in whom there was no clinical or physiologic evidence of failure. There was either a fall or no change in the cardiac output and the intracardiac pressures did not alter following administration of the drug. The reaction to Digoxin in this type of patient with heart disease was in no way different from the response seen in two normal subjects included in the study but is in sharp contrast to the response elicited in patients in congestive heart failure.

This article has been cited by other articles:

				L. Gould, A. F. Lyon, S. Ettinger, F. X. McGinn, and M. Di Lieto The Effect of Stepwise Doses of Digitalis On Hemodynamic Function in Man Angiology, January 1, 1970; 21(7): 468 - 485. [PDF]