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(Circulation. 1951;4:378.)
© 1951 American Heart Association, Inc.

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The Effect of Intravenously Administered Digoxin on Water and Electrolyte Excretion and on Renal Functions

SAUL J. FARBER M.D.¹; J. D. ALEXANDER M.D.¹; E. D. PELLEGRINO M.D.¹; D. P. EARLE M.D.¹

¹ From The Department of Medicine, New York University College of Medicine, and Bellevue Hospital, New York City, N. Y.

Digoxin causes a prompt and considerable water and salt diuresis in congestive heart failure. This may occur with little or no change in renal hemodynamics, but usually is associated with decreased venous pressure. At times, increased glomerular filtration rate may contribute to the diuresis. In patients with noncardiac edema and without edema, Digoxin may also initiate a slight but definite sodium diuresis. This effect is not as great as in patients with congestive heart failure and apparently is not associated with changes in renal hemodynamics, cardiac output or venous pressure.