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(Circulation. 1951;4:679.)
© 1951 American Heart Association, Inc.

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The Distribution of Body Fluids In Congestive Heart Failure

I. Theoretic Considerations

J. R. ELKINTON M.D.¹ R. D. SQUIRES M.D.¹

¹ From the Chemical Section of the Department of Medicine and the Hospital of the University of Pennsylvania, Philadelphia, Pa.

The pathogenesis of congestive heart failure is discussed. Experimental evidence is cited to support the thesis that abnormalities in the distribution of body fluids may affect circulatory and renal function, and hence may be a cause as well as an effect in the complex sequence of events leading to the congestive state. Emphasis is placed upon alterations in cellular metabolism which may lead to such disturbances in body fluids and so through various mechanisms, cellular, humoral, and circulatory, may modify the volume regulation of the body.

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