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(Circulation. 1951;4:747.)
© 1951 American Heart Association, Inc.

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Experimental Arterial Disease

I. The Reaction of the Pulmonary Artery to Minute Emboli of Blood Clot

WILLIAM B. WARTMAN M.D.¹; ROBERT B. JENNINGS M.D.¹; BRYAN HUDSON M.D.¹

¹ From the Department of Pathology, Northwestern University Medical School and Passavant Memorial, Wesley Memorial and Children's Memorial Hospitals and the Evanston Hospital Association, Chicago, Ill.

When emboli of rabbit blood measuring 0.5 mm. in average diameter were injected into the ear vein of healthy adult male rabbits, they either became adherent to the walls of the pulmonary arteries or impacted in them. In either case an acute arteritis accompanied by endothelial proliferation regularly occurred. This process was reversible in some instances but in others was followed by organization of emboli which resulted in eccentric fibroelastic thickening of the intima or formation of fibrous intravascular bridges. Fatty degeneration, calcification, hemorrhage, and atheroma were absent. The lesions were self-limited and healed. They were not progressive.

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