1 From the Mayo Clinic and Mayo Foundation: Section of Pediatrics and of Experimental and Anatomic Pathology, and the Mayo Graduate School of Medicine (University of Minnesota), Rochester, Minnesota.
Obstructive pulmonary vascular disease (PVD) was evaluated in lung sections taken at autopsy in 53 patients with complete transposition of the great arteries. Twentythree had intact ventricular septa and 30 had ventricular septal defects. Children of similar age and associated defects had widely differing degrees of PVD and presented a spectrum of disease. In a small number of patients, the presence of pulmonic stenosis (congenital or acquired by pulmonary artery banding in infancy), a small ventricular septal defect, or a large atrial septal defect was not protective against the development of severe PVD. The findings of this study demonstrate the need for thorough hemodynamic evaluation of patients with complete transposition of the great arteries prior to repair by present technics. In addition, operation should probably be performed as soon as technically feasible.
© 1969 American Heart Association, Inc.
The Spectrum of Pulmonary Vascular Disease in Transposition of the Great Arteries
Key Words: Ventricular septal defect • Pulmonary banding • Pulmonary stenosis • Pulmonary hypertension
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