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(Circulation. 1969;40:583.)
© 1969 American Heart Association, Inc.

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Primary Pulmonary Hypertension in a Child

Response to Pharmacologic Agents

B. N. SATYANARAYANA RAO M.B., B.S.¹; JAMES H. MOLLER M.D.¹; JESSE E. EDWARDS M.D.¹

¹ From the Department of Pathology, the Charles T. Miller Hospital, St. Paul, Minnesota, and the Departments of Pediatrics and Pathology, University of Minnesota, Minneapolis, Minnesota.

Clinical, pharmacologic, and pathologic findings presented are those in a 12-year-old boy with primary pulmonary hypertension associated with medial hypertrophy of the pulmonary muscular arteries and arterioles.

Intrapulmonary arterial administration of acetylcholine, tolazoline (Priscoline), or isoproterenol resulted in a fall in pulmonary vascular resistance and pressure.

Perforation of the right ventricle by an indwelling catheter terminated studies on the results of long-term intrapulmonary arterial administration of drugs shown to be effective.

Key Words: Acetylcholine • Tolazoline • Isoproterenol • Intrapulmonary arterial drug therapy

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