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(Circulation. 1969;40:IV-5.)
© 1969 American Heart Association, Inc.

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Etiology and Pathogenesis of Acute Myocardial Infarction

What Is Myocardial Infarction?

Thomas Killip III ¹ JESSE E. EDWARDS M.D.¹

¹ From the Departments of Pathology, The Charles T. Miller Hospital, St. Paul, Minnesota, and the University of Minnesota, Minneapolis, Minnesota.

From the pathological viewpoint, myocardial infarction is but one major consequence of coronary atherosclerosis. Among subjects with chronic occlusive coronary atherosclerosis, more common than death from acute myocardial infarction is death occurring acutely in the absence of infarction or acute coronary occlusion.

Such negative anatomical evidence is supportive of the concept that myocardial ischemia commonly causes serious failure of the circulation through certain ventricular arrhythmias.