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(Circulation. 1970;41:309.)
© 1970 American Heart Association, Inc.

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Study of Nailfold Capillaries in Hypertriglyceridemia (Types III and IV Hyperlipoproteinemia)

PETER T. KUO M.D.¹; LOUISE Y. FENG PH.D.¹; JOSÉ PAMINTAUN M.D.¹

¹ From the Cardiac Section of the Department of Medicine, the Robinette Foundation for Cardiovascular Research, and the George S. Klump Laboratory, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania.

Reflected light nailfold capillaroscopy was used to discover micro-angiopathy in atherosclerotic patients with hypertriglyceridemia (types III and IV hyperlipoproteinemia). In comparison with healthy normolipemic controls, 51 of a series of 64 patients were found to have beds of dilated, congested, elongated, and tortuous capillary venular limbs and loops; and 29 of these with capillary abnormalities were found to have either fresh or old hemorrhages. Serial studies revealed that capillary hemorrhages tended to subside shortly after the hyperlipoproteinemia was controlled by a low carbohydrate diet, while the morphologic abnormalities showed little or no change for 8 to 21 months.

Key Words: Atherosclerosis • Capillaroscopy • Coronary artery disease • Micro-angiopathy • Hyperlipemia

Submitted on May 27, 1969
Accepted on October 31, 1969