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(Circulation. 1970;41:II-98.)
© 1970 American Heart Association, Inc.

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Pathogenesis of Rejection of Canine Cardiac Allografts

K. H. SHUMAK M.D.¹; B. S. GOLDMAN M.D.¹; M. D. SILVER M.B.¹; W. G. BIGELOW M.D.¹; J. H. CROOKSTON M.D.¹

¹ From the Departments of Medicine, Surgery, and Pathology, University of Toronto, and Toronto General Hospital, Toronto, Canada.

Cardiac rejection was studied in 25 mongrel dogs receiving heterotopic abdominal cardiac allografts from unrelated donors. Seventeen recipients were not given immunosuppressive therapy; the other eight were treated with antilymphocyte serum. Antibodies cytotoxic to dog lymphocytes were detected in the serum of five dogs after transplantation. Immunofluorescence studies showed the presence of IgG deposits on the sarcolemma of hearts undergoing rejection. In addition, there were focal IgG deposits on many of the recipients' own hearts, including five which showed changes of focal myocarditis when stained with hematoxylin and eosin. In the dogs treated with antilymphocyte serum, rejection was delayed, and the histological changes were modified. However, the development of lymphocytotoxic antibody and the deposition of IgG were unaffected.