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(Circulation. 1970;42:781.)
© 1970 American Heart Association, Inc.

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Autologous Pulmonary Valve Replacement of the Diseased Aortic Valve

L. GONZALEZ-LAVIN M.D.¹; M. GEENS M.D.¹; J. SOMERVILLE M.D., M.R.C.P.¹; D. N. ROSS M.B., CH.B., F.R.C.S.¹

¹ From the Department of Surgery, National Heart Hospital, and the Institute of Cardiology, London, England.

Living tissue has the potential to replace and reestablish its structure and, therefore, offers the best hope for permanent replacement of diseased cardiac valves. The autologous pulmonary valve has been used to replace the aortic valve in 97 patients since June 1967. An aortic homograft valve, and more recently an autologous conduit of fascia lata, containing a valvular structure, has been used to reconstruct the right ventricular outflow tract. Only four deaths have occurred among the last 50 patients, an 8% operative mortality. Histologic examination of valves, 1 and 13 mo after implantation, revealed normal architecture of cells and collagen fibers with normal living structures.

This initial experience has encouraged the authors to pursue this method of aortic valve replacement in selected cases.

Key Words: Living structure • Biological tissue • Autologous tissue

Submitted on November 28, 1969
Accepted on July 16, 1970