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(Circulation. 1970;42:867.)
© 1970 American Heart Association, Inc.

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Tritiated Digoxin

XIV. Enterohepatic Circulation, Absorption, and Excretion Studies in Human Volunteers

JAMES E. DOHERTY M.D.¹; W. J. FLANIGAN M.D.¹; M. L. MURPHY M.D.¹; R. T. BULLOCH M.D.¹; G. L. DALRYMPLE M.D.¹; O. W. BEARD M.D.¹; W. H. PERKINS M.D.¹; Jacquelyn Gammill B.S., M.T. (ASCP)¹; Joyce Sherwood B.S., M.T. (ASCP)¹

¹ From the Departments of Medicine, Pharmacology, and Nuclear Medicine, University of Arkansas Medical Center and Little Rock Veterans Administration Hospital, Little Rock, Arkansas.

Metabolic turnover studies performed on six patients with surgically induced biliary fistula given tritiated digoxin reveal virtually all stool excretion of digoxin to be derived from bile. This establishes the relative lack of recycling of digoxin as an important factor in digoxin metabolism. This is probably related to its polar chemical structure and is a determinant of its clinical duration of action in human subjects. The amount of digoxin in the enterohepatic circulation (recycling) was calculated to be 6.5% of the administered dose and absolute absorption to be 85% in human subjects.

Key Words: Biliary fistula • Digoxin, metabolism of

Submitted on May 25, 1970
Accepted on July 23, 1970

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