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(Circulation. 1971;43:382.)
© 1971 American Heart Association, Inc.

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Relationship Between Cardiac Output and Peripheral Resistance in Borderline Hypertension

STEVO JULIUS M.D., SC.D.¹; ARTURO V. PASCUAL M.D.¹; RUNE SANNERSTEDT M.D., PH.D.¹; CHARLES MITCHELL B.SC.¹

¹ From the Department of Internal Medicine (Hypertension Unit), University of Michigan Medical School, Ann Arbor, Michigan 48104.

Eighty-eight observations on 77 patients with borderline hypertension and 82 single observations in healthy control subjects are reported. Hemodynamic effects of assumption of the sitting position, mild exercise, infusion of dextran, blockade with propranolol and with a combination of propranolol and atropine are evaluated. In the recumbent position, patients with borderline hypertension have increased cardiac output and "normal" peripheral resistance. Under all other experimental conditions, the peripheral resistance in patients with borderline hypertension was elevated. Increased resistance was accompanied by a decrease of the cardiac output. After administration of the atropine and propranolol combination, cardiac output in patients with borderline hypertension was significantly below the normal. Nevertheless, whether cardiac output was high or low and resistance normal or elevated, patients with borderline hypertension maintained mild elevations of the blood pressure. Consequently, borderline hypertension is not caused solely by elevations of cardiac output.

Key Words: Volume expansion • Exercise Dextran • Propranolol Atropine

Submitted on August 25, 1970
Accepted on November 12, 1970

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