This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by BROWN, W. J. Articles by KRISHAN, I. Search for Related Content PubMed PubMed Citation Articles by BROWN, W. J., JR. Articles by KRISHAN, I.

(Circulation. 1971;43:508.)
© 1971 American Heart Association, Inc.

---

Exchangeable Sodium and Blood Volume in Normotensive and Hypertensive Humans on High and Low Sodium Intake

WALTER J. BROWN JR. M.D.¹; FAITH K. BROWN M.S.¹; IQBAL KRISHAN M.D.¹

¹ From the Departments of Medicine and Physiology, Medical College of Georgia, Augusta, Georgia, and the Department of Physiology and Pharmacology, College of Veterinary Medicine and the Institute of Comparative Medicine, University of Georgia, Athens, Georgia.

Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured. Plasma and nonplasma sodium fractions, nonplasma weight, and plasma, cell, and whole blood volumes, as referred to body weight and height, were calculated. Changes in these parameters with diet were also calculated. Specific differences between normotensives and hypertensives were found, in absolute values and with changes with diet. The hypertensives fell into two groups with regard to exchangeable sodium: in four the values varied with diet and in the other four, the values remained low regardless of diet. The "variable-sodium" patients had high upright arterial pressures when on high salt intake and normal upright pressures when on low salt intake. "Low-sodium" patients had high arterial pressures on both diets. Changes in upright pressures of hypertensives correlated significantly (r = 0.73) with changes in nonplasma exchangeable sodium.

Key Words: Hypertension (human) • Sodium intake in diet • Plasma volume • Blood cell volume

Submitted on August 14, 1970
Accepted on December 16, 1970

This article has been cited by other articles:

				L. A. Barron, G. M. Green, and R. A. Khalil Gender Differences in Vascular Smooth Muscle Reactivity to Increases in Extracellular Sodium Salt Hypertension, February 1, 2002; 39(2): 425 - 432. [Abstract] [Full Text] [PDF]

				D. M. Medeiros and R. F. Borgman Blood ressure in South Carolina children; dietary aspects Perspectives in Public Health, April 1, 1984; 104(2): 68 - 70.

				E. REISIN, E. D. FROHLICH, F. H. MESSERLI, G. R. DRESLINSKI, F. G. DUNN, M. M. JONES, and H. M. BATSON Jr. Cardiovascular Changes After Weight Reduction in Obesity Hypertension Ann Intern Med, March 1, 1983; 98(3): 315 - 319. [Abstract] [PDF]

				W. J. Brown JR, F. K. Brown, and I. Krishan Stabilized Venous Distensibility of Normotensive and Hypertensive Humans On High and Low Sodium Intake Angiology, July 1, 1976; 27(7): 433 - 442. [PDF]

				R. M. Lauer, L. J. Filer Jr, M. A. Reiter, and W. R. Clarke Blood Pressure, Salt Preference, Salt Threshold, and Relative Weight Arch Pediatr Adolesc Med, May 1, 1976; 130(5): 493 - 497. [Abstract] [PDF]